Topical use may induce severe local erythema and peeling at the site of application. RETIN-A (tretinoin) acne treatment should be kept away from the eyes, the mouth, angles of the nose, and mucous membranes. Weather extremes, such as wind or cold, also may be irritating to patients under treatment with tretinoin. Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided. Patients who may be required to have considerable sun exposure due to occupation and those with inherent sensitivity to the sun should exercise particular caution. Exposure to sunlight, including sunlamps, should be minimized during the use of RETIN-A, and patients with sunburn should be advised not to use the product until fully recovered because of heightened susceptibility to sunlight as a result of the use of tretinoin. If a reaction suggesting sensitivity or chemical irritation occurs, use of the medication should be discontinued. Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted. The safety and efficacy of the long-term use of this product in the treatment of other disorders have not been established. RETIN-A is indicated for topical application in the treatment of acne vulgaris. Additionally, tretinoin stimulates mitotic activity and increased turnover of follicular epithelial cells causing extrusion of the comedones. Related/similar drugs prednisone, doxycycline, clindamycin topical, erythromycin topical, tetracycline, tretinoin topical, Retin-A Clinical PharmacologyĪlthough the exact mode of action of tretinoin is unknown, current evidence suggests that topical tretinoin decreases cohesiveness of follicular epithelial cells with decreased microcomedo formation.
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